Journal
NATURE GENETICS
Volume 35, Issue 3, Pages 213-214Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1252
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Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats.
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