Journal
CELL AND TISSUE RESEARCH
Volume 349, Issue 3, Pages 825-838Publisher
SPRINGER
DOI: 10.1007/s00441-012-1356-1
Keywords
Endometrium; Conceptus; Pregnancy; Interleukin-1 beta; Nuclear factor kappa-B
Categories
Funding
- USDA Cooperative State Research, Education, and Extension Service [2007-35203-17836]
- [NIH HD 42280]
Ask authors/readers for more resources
Implantation and the establishment of pregnancy in mammals involves an intricate interplay of hormones, cytokines, growth factors, proteins, lipids, ions and the extracellular matrix between the uterine epithelium, stroma, immune cells and the conceptus trophectoderm. The divergent nature of implantation in the mouse, human and pig provides not only an interesting contrast in the establishment of pregnancy and early embryonic development but also intriguing similarities with regard to early endometrial-conceptus signaling. An interesting pro-inflammatory cytokine expressed in a number of mammalian species during the period of implantation is interleukin-1 beta (IL1B). The presence of IL1B might be involved with immunotolerance at the maternal-placental interface and has been proposed as one of the mediators in placental viviparity. The production of IL1B and other proinflammatory cytokines might play a role in establishing pregnancy through modulation of the nuclear factor kappa-B (NFKB) system in a number of species. A model for the regulation of cellular progesterone receptor expression and NFKB activation for endometrial receptivity and conceptus attachment is continuing to evolve and is discussed in the present review.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available