Journal
GENES & DEVELOPMENT
Volume 17, Issue 21, Pages 2642-2647Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1122903
Keywords
Arabidopsis; photomorphogenesis; phytochrome; protein; degradation; ubiquitination; protein complex
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM047850, R29GM047850, R37GM047850] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM047850, R37 GM047850, GM47850] Funding Source: Medline
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Arabidopsis COP1 is a constitutive repressor of photomorphogenesis that interacts with photomorphogenesis-promoting factors such as HY5 to promote their proteasome-mediated degradation. SPA1 is a repressor of phytochrome A-mediated responses to far-red light. Here we report that COP1 acts as part of a large protein complex and interacts with SPA1 in a light-dependent manner. We further demonstrate the E3 ubiquitin ligase activity of COP1 on HY5 in vitro and the alteration of that activity by SPA1. Thus, the COP1-SPA1 interaction defines a critical step in coordinating COP1-mediated ubiquitination and subsequent degradation of HY5 with PHYA signaling.
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