Journal
CELL AND TISSUE RESEARCH
Volume 343, Issue 1, Pages 175-188Publisher
SPRINGER
DOI: 10.1007/s00441-010-1022-4
Keywords
Defensins; Antimicrobial activity; Inflammation; Ocular immunity; Clinical significance
Categories
Funding
- NEI NIH HHS [R01 EY002986] Funding Source: Medline
Ask authors/readers for more resources
The innate immune system is the first line of defense against many common microorganisms, which can initiate adaptive immune responses to provide increased protection against subsequent re-infection by the same pathogen. As a major family of antimicrobial peptides, defensins are widely expressed in a variety of epithelial cells and sometimes in leukocytes, playing an important role in the innate immune system due to their antimicrobial, chemotactic and regulatory activities. This review introduces their structure, classification, distribution, synthesis, and focuses on their biological activities and mechanisms, as well as clinical relevance. These studies of defensins in the innate immune system have implications for the prevention and treatment of a variety of infectious diseases, including bacterial ocular disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available