Journal
CELL AND TISSUE RESEARCH
Volume 343, Issue 1, Pages 153-165Publisher
SPRINGER
DOI: 10.1007/s00441-010-1044-y
Keywords
Pneumonia; Innate immunity; NF-kappa B; STAT3; Transcriptional regulation
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R00HL092956] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R00 HL092956] Funding Source: Medline
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Innate immune responses to lung pathogens involve the coordinated expression of myriad affector and effector molecules of innate immunity, which must be induced and appropriately regulated in response to diverse stimuli generated by microbes or the infected host. Many intercellular and intracellular signaling pathways are involved, but we propose NF-kappa B and STAT3 transcription factors to be especially important signaling hubs for integrating these pathways to orchestrate effective host defense without excessive inflammatory injury.
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