Journal
ACTA NEUROPATHOLOGICA
Volume 106, Issue 6, Pages 557-560Publisher
SPRINGER-VERLAG
DOI: 10.1007/s00401-003-0759-1
Keywords
regeneration; inhibitory; excitatory; anterior horn; dendrite
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Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.
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