Journal
CELL AND TISSUE RESEARCH
Volume 339, Issue 1, Pages 111-120Publisher
SPRINGER
DOI: 10.1007/s00441-009-0857-z
Keywords
Integrin; Cell adhesion; Growth factor; Signaling; Endocytosis
Categories
Funding
- European Research Council [202809] Funding Source: Medline
Ask authors/readers for more resources
The emergence of multicellular animals could only take place once evolution had produced molecular mechanisms for cell adhesion and communication. Today, all metazoans express integrin-type adhesion receptors and receptors for growth factors. Integrins recognize extracellular matrix proteins and respective receptors on other cells and, following ligand binding, can activate the same cellular signaling pathways that are regulated by growth factor receptors. Recent reports have indicated that the two receptor systems also collaborate in many other ways. Here, we review the present information concerning the role of integrins as assisting growth factor receptors and the interplay between the receptors in cell signaling and in the orchestration of receptor recycling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available