Journal
VISION RESEARCH
Volume 43, Issue 28, Pages 2983-2990Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0042-6989(03)00475-9
Keywords
aging; atrophy; lipofuscin; retinal pigment epithelium; retinoids
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Funding
- NEI NIH HHS [EY 12951] Funding Source: Medline
- NIGMS NIH HHS [GM 36564] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY012951] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM036564] Funding Source: NIH RePORTER
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A substantial portion of the lipofuscin that accumulates with age and in some retinal disorders in retinal pigment epithelial (RPE) cells, forms as a consequence of light-related vitamin A recycling. Major constituents of RPE lipofuscin are the di-retinal conjugate A2E and its photoisomers. That the accretion of A2E has consequences for the cell, with the adverse effects of A2E being attributable to its amphiphilic structure and its photoreactivity, is consistent with evidence of an association between atrophic age-related macular degeneration (AMD) and excessive lipofuscin accumulation. (C) 2003 Elsevier Ltd. All rights reserved.
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