Journal
CELL AND TISSUE RESEARCH
Volume 335, Issue 1, Pages 5-16Publisher
SPRINGER
DOI: 10.1007/s00441-008-0706-5
Keywords
Vascular endothelial cells; Specification; ephrinB2; EphB4; VEGF; Notch
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Funding
- NEI NIH HHS [R01 EY015435, EY015435, R01 EY005318, EY05318] Funding Source: Medline
- NHLBI NIH HHS [T32 HL076115] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY015435, R01EY005318] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL076115] Funding Source: NIH RePORTER
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Vascular endothelial cells (ECs) form the inner lining of all blood vessels from the largest artery and veins, viz., the aorta and venae cavae, respectively, to the capillaries that connect the arterial and venous systems. Because these two major conducting systems of the cardiovasculature differ functionally, it is not surprising that the physical makeup of arteries and veins, including the ECs that line their lumina, are also distinct. Although few would argue that the local environment contributes to the differences between arteries and veins, recent evidence has shown that the specification of arterial and venous identity is largely genetically determined.
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