Journal
GENOME RESEARCH
Volume 13, Issue 1, Pages 1-12Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gr.222003
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Funding
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [F32HG002325, R01HG002238] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK027635] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM057482] Funding Source: NIH RePORTER
- NATIONAL LIBRARY OF MEDICINE [Z01LM000160] Funding Source: NIH RePORTER
- NHGRI NIH HHS [F32 HG002325, HG02325, R01 HG002238, HG02238] Funding Source: Medline
- NIDDK NIH HHS [DK27635] Funding Source: Medline
- NIGMS NIH HHS [GM-5748202] Funding Source: Medline
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With the availability of whole-genome sequences for an increasing number of species, we are now faced with the challenge of decoding the information contained within these DNA sequences. Comparative analysis of DNA sequences from multiple species at varying evolutionary distances is a powerful approach for identifying coding and functional noncoding sequences, as well as sequences that are unique for a given organism. In this review, we outline the strategy for choosing DNA sequences from different species for comparative analyses and describe the methods used and the resources publicly available for these studies.
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