Journal
CELL AND TISSUE BANKING
Volume 13, Issue 2, Pages 203-215Publisher
SPRINGER
DOI: 10.1007/s10561-011-9248-2
Keywords
Dimethyl sulfoxide; Adverse reactions; Stem cells; Transplantation; Toxicity
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A retrospective review of the published literature identified several hundred adverse reactions (e. g. nausea, chills, cardiac arrhythmias, neurological symptoms and respiratory arrest) associated with the transplantation of stem cells cryopreserved with dimethyl sulfoxide. The occurrences of these are generally accepted as commonplace, as the majority of reactions are transient, whilst a few patients may require clinical treatment. This exploratory study is a collation of the historical data and the expectations for the notification of serious adverse reactions. Outline information is presented on the development of related European Directives, some technical aspects of dimethyl sulfoxide and the sequential stages of preservation and administration.
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