Journal
INTERNAL MEDICINE
Volume 42, Issue 1, Pages 72-77Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.42.72
Keywords
M protein; plasma cell dyscrasia; chemotherapy
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Primary AL amyloidosis involves vital organs from the early phase of illness, resulting in a poor prognosis. We report a patient with nephrotic syndrome due to this type of amyloidosis, who was successfully treated with two courses of VAD (vincristine, doxorubicin and dexamethasone) and subsequent high-dose melphalan (140 mg/m(2)) with autologous stem cell support. Following the serial chemotherapy his proteinuria improved, and M protein became undetectable in both serum and urine. To avoid the progression of primary AL amyloidosis, intensive chemotherapy should be actively used when the general status and vital organ functions are well preserved.
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