Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 22, Issue 5-8, Pages 1495-1497Publisher
MARCEL DEKKER INC
DOI: 10.1081/NCN-120023019
Keywords
surface immobilization; bioconjugation; aqueous Diels-Alder reaction
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The synthesis of cyclohexadiene and maleimide derivatives and their use for the functionalization of oligonucleotides and the coating of glass surfaces is reported. A method for the covalent attachment of diene or maleimide modified oligonucleotides to the coated glass surfaces via aqueous Diels-Alder reactions is presented.
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