Journal
CELL
Volume 174, Issue 4, Pages 999-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2018.06.021
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Funding
- Knut and Alice Wallenberg Foundation [2015.0041]
- Swedish Foundation for Strategic Research (SSF) [RIF 14-0057, SB16-0065]
- Wellcome Trust [108726/Z/15/Z]
- Swedish Research Council [2016-01526, 2016-03130]
- SSF (SRL) [SB160065]
- Cancerfonden [CAN 2016/572]
- EU
- Hjarnfonden [FO2017-0059]
- SFO Strat Regen (SG-2018)
- European Research Council [740491]
- Ollie and Elof Ericssons Foundation
- Ake Wiberg Foundation [M16-0197]
- Hjarnfonden
- Swedish Research Council [2016-03130] Funding Source: Swedish Research Council
- European Research Council (ERC) [740491] Funding Source: European Research Council (ERC)
- Swedish Foundation for Strategic Research (SSF) [SB16-0065] Funding Source: Swedish Foundation for Strategic Research (SSF)
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The mammalian nervous system executes complex behaviors controlled by specialized, precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a million single cells to create a detailed census of cell types in the mouse nervous system. We mapped cell types spatially and derived a hierarchical, data-driven taxonomy. Neurons were the most diverse and were grouped by developmental anatomical units and by the expression of neurotransmitters and neuropeptides. Neuronal diversity was driven by genes encoding cell identity, synaptic connectivity, neurotransmission, and membrane conductance. We discovered seven developmental boundaries and correlated with the spatial distribution of key glutamate and glycine neurotransmitters. In contrast, oligodendrocytes showed a loss of regional identity followed by a secondary diversification. The resource presented here lays a solid foundation for understanding the molecular architecture of the mammalian nervous system and enables genetic manipulation of specific cell types.
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