4.8 Review

Microbiome: Focus on Causation and Mechanism

Journal

CELL
Volume 174, Issue 4, Pages 785-790

Publisher

CELL PRESS
DOI: 10.1016/j.cell.2018.07.038

Keywords

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Funding

  1. HHMI-Simons Faculty Scholar Award
  2. Fellowship for Science and Engineering from the David and Lucile Packard Foundation
  3. Investigators in the Pathogenesis of Infectious Disease award from the Burroughs Wellcome Foundation
  4. BASF
  5. Leducq Foundation
  6. NIH [DK110174, DK113598, DK101674, AI101018]

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There is tremendous enthusiasm for the microbiome in academia and industry. This Perspective argues that in order to realize its potential, the field needs to focus on establishing causation and molecular mechanism with an emphasis on phenotypes that are large in magnitude, easy to measure, and unambiguously driven by the microbiota.

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