Journal
CELL
Volume 174, Issue 4, Pages 780-784Publisher
CELL PRESS
DOI: 10.1016/j.cell.2018.07.030
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Funding
- UK Medical Research Council [MC_UU_00015/5]
- Wellcome Trust Investigator award [110159/Z/15/Z, 205455]
- MRC [MC_UU_00015/8, MC_UU_00015/3] Funding Source: UKRI
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Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.
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