Journal
CELL
Volume 174, Issue 5, Pages 1049-1051Publisher
CELL PRESS
DOI: 10.1016/j.cell.2018.08.007
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Funding
- Wellcome Trust
- Brunel Idea Award
- Wellcome Trust Investigator Award in Science
- Medical Research Council [MC_UU_12016/2]
- Michael J. Fox Foundation [6986]
- BBSRC [BB/K017632/1] Funding Source: UKRI
- MRC [MC_UU_12016/2, MC_UU_00018/1] Funding Source: UKRI
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The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.
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