Journal
CELL
Volume 157, Issue 1, Pages 151-161Publisher
CELL PRESS
DOI: 10.1016/j.cell.2014.02.039
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Funding
- Wyss Institute
- DARPA
- ONR
- HHMI
- DOE
- NIH
- NSF
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Synthetic biology seeks to extend approaches from engineering and computation to redesign of biology, with goals such as generating new chemicals, improving human health, and addressing environmental issues. Early on, several guiding principles of synthetic biology were articulated, including design according to specification, separation of design from fabrication, use of standardized biological parts and organisms, and abstraction. We review the utility of these principles over the past decade in light of the field's accomplishments in building complex systems based on microbial transcription and metabolism and describe the progress in mammalian cell engineering.
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