Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 22, Issue 5-8, Pages 1331-1333Publisher
TAYLOR & FRANCIS INC
DOI: 10.1081/NCN-120022958
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To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synthesized in 7 steps starting from commercially available dimethyl 2-oxoglutarate.
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