Journal
CELL
Volume 156, Issue 5, Pages 1072-1083Publisher
CELL PRESS
DOI: 10.1016/j.cell.2014.01.044
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Funding
- NIHR Cambridge Biomedical Research Centre
- Swedish Research Council
- Swedish Cancer Society
- Karolinska Institute
- Tobias Stiftelsen
- AFA Forsakringar
- Strategic Research Programme in Stem Cells and Regenerative Medicine at Karolinska Institutet (StratRegen)
- ERC
- Knut och Alice Wallenbergs Stiftelse
- Stockholm County Council
- Karolinska Institutet [ALF 20080508]
- Torsten Soderbergs Stiftelse
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In most mammals, neurons are added throughout life in the hippocampus and olfactory bulb. One area where neuroblasts that give rise to adult-born neurons are generated is the lateral ventricle wall of the brain. We show, using histological and carbon-14 dating approaches, that in adult humans new neurons integrate in the striatum, which is adjacent to this neurogenic niche. The neuronal turnover in the striatum appears restricted to interneurons, and postnatally generated striatal neurons are preferentially depleted in patients with Huntington's disease. Our findings demonstrate a unique pattern of neurogenesis in the adult human brain.
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