Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 49, Issue 1, Pages 177-182Publisher
WILEY
DOI: 10.1002/mrm.10308
Keywords
diffusion MRI; eddy currents; image distortion; pulse sequence; artifact
Funding
- NIMH NIH HHS [R01 MH64044] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH064044] Funding Source: NIH RePORTER
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Image distortion due to field gradient eddy currents can create image artifacts in diffusion-weighted MR images. These images, acquired by measuring the attenuation of NMR signal due to directionally dependent diffusion, have recently been shown to be useful in the diagnosis and assessment of acute stroke and in mapping of tissue structure. This work presents an improvement on the spin-echo (SE) diffusion sequence that displays less distortion and consequently improves image quality. Adding a second refocusing pulse provides better image quality with less distortion at no cost in scanning efficiency or effectiveness, and allows more flexible diffusion gradient timing. By adjusting the timing of the diffusion gradients, eddy currents with a single exponential decay constant can be nulled, and eddy currents with similar decay constants can be greatly reduced. This new sequence is demonstrated in phantom measurements and in diffusion anisotropy images of normal human brain. (C) 2003 Wiley-Liss, Inc.
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