Journal
CELL
Volume 157, Issue 6, Pages 1257-1261Publisher
CELL PRESS
DOI: 10.1016/j.cell.2014.05.019
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Funding
- NCI NIH HHS [P30 CA034196] Funding Source: Medline
- NIGMS NIH HHS [R01 GM045415] Funding Source: Medline
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Germ cells are the ultimate stem cells, and reports of their in vitro derivation generate excitement due to potential applications in reproductive medicine. To date, there is no firm evidence that meiosis, the hallmark of gametogenesis, can be faithfully replicated outside of the gonad. We propose benchmarks for evaluating in vitro derivation of germ cells, facilitating realization of their potential.
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