Journal
CELL
Volume 158, Issue 2, Pages 243-244Publisher
CELL PRESS
DOI: 10.1016/j.cell.2014.06.039
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Funding
- NIGMS NIH HHS [R01 GM046638, R01 GM034431, R37 GM046638] Funding Source: Medline
- NINDS NIH HHS [R01 NS076542] Funding Source: Medline
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Lucas et al. report the visualization of V(D)J recombination of the immunoglobulin heavy-chain gene (Igh) in living pro-B cells. Despite the huge distances separating V coding sequences from D-J sequences (similar to 2 Mb), the authors document an astonishingly rapid rate of remote associations. The key to speed is contraction of the Igh chromosomal domain. These findings provide a foundation for understanding long-range regulatory interactions in a variety of developmental processes, including the patterning of vertebrate limbs.
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