Journal
CELL
Volume 158, Issue 5, Pages 973-975Publisher
CELL PRESS
DOI: 10.1016/j.cell.2014.08.013
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R01 GM055040, P50 GM081879, R01 GM062583] Funding Source: Medline
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Cells often receive signals to proliferate, but how population density is controlled is unclear. Hart et al. now show that a single secreted molecule that instructs both proliferation and death in T cells establishes a bistable response: the population is driven to either extinction or to a homeostatically defined density.
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