Journal
CELL
Volume 157, Issue 4, Pages 832-844Publisher
CELL PRESS
DOI: 10.1016/j.cell.2014.04.016
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Funding
- Japan Society for the Promotion of Science (JSPS)
- Uehara Memorial Foundation
- Kanae Foundation for the Promotion of Medical Science
- Blavatnik Family Foundation
- NIH [AI046688, AI089771, CA157461]
- Howard Hughes Medical Institute
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Tissue-resident macrophages are highly heterogeneous in terms of their functions and phenotypes as a consequence of adaptation to different tissue environments. Local tissue-derived signals are thought to control functional polarization of resident macrophages; however, the identity of these signals remains largely unknown. It is also unknown whether functional heterogeneity is a result of irreversible lineage-specific differentiation or a consequence of continuous but reversible induction of diverse functional programs. Here, we identified retinoic acid as a signal that induces tissue-specific localization and functional polarization of peritoneal macrophages through the reversible induction of transcription factor GATA6. We further found that GATA6 in macrophages regulates gut IgA production through peritoneal B-1 cells. These results provide insight into the regulation of tissue-resident macrophage functional specialization by tissue-derived signals.
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