Journal
CELL
Volume 156, Issue 6, Pages 1129-1131Publisher
CELL PRESS
DOI: 10.1016/j.cell.2014.02.037
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Funding
- NCI NIH HHS [U24 CA143883] Funding Source: Medline
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Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.
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