Journal
CELL
Volume 157, Issue 7, Pages 1515-1526Publisher
CELL PRESS
DOI: 10.1016/j.cell.2014.05.031
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Funding
- Austrian Science Fund FWF [SFB-LIPO-TOX F3007, F3012, P23490-B12, P24381-B20, W1226-B18]
- European Commission for project APOSYS
- Intramural Research Program of the National Institute on Aging
- National Institutes of Health
- Swiss National Science Foundation
- Austrian Science Fund (FWF) [P 24381, P 23490] Funding Source: researchfish
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The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to manipulate it has fascinated humans likely since time immemorial. Recent evidence is shaping a picture where low caloric regimes and exercise may improve healthy senescence, and several pharmacological strategies have been suggested to counteract aging. Surprisingly, the most effective interventions proposed to date converge on only a few cellular processes, in particular nutrient signaling, mitochondrial efficiency, proteostasis, and autophagy. Here, we critically examine drugs and behaviors to which life- or healthspan-extending properties have been ascribed and discuss the underlying molecular mechanisms.
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