Journal
CELL
Volume 154, Issue 4, Pages 843-858Publisher
CELL PRESS
DOI: 10.1016/j.cell.2013.07.014
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Funding
- Cancer Research UK
- European Research Council (ERC) [AdG-2010-268670]
- EMBO long-term fellowship
- Boehringer Ingelheim Fonds
- Overseas Biomedical Fellowship from the NHMRC of Australia
- Henry Wellcome Fellowship [WT089009MA]
- Cancer Research UK [15689] Funding Source: researchfish
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Mononuclear phagocytes are classified as macrophages or dendritic cells (DCs) based on cell morphology, phenotype, or select functional properties. However, these attributes are not absolute and often overlap, leading to difficulties in cell-type identification. To circumvent this issue, we describe a mouse model to define DCs based on their ontogenetic descendence from a committed precursor. We show that precursors of mouse conventional DCs, but not other leukocytes, are marked by expression of DNGR-1. Genetic tracing of DNGR-1 expression history specifically marks cells traditionally ascribed to the DC lineage, and this restriction is maintained after inflammation. Notably, in some tissues, cells previously thought to be monocytes/macrophages are in fact descendants from DC precursors. These studies provide an in vivo model for fate mapping of DCs, distinguishing them from other leukocyte lineages, and thus help to unravel the functional complexity of the mononuclear phagocyte system.
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