Journal
CELL
Volume 152, Issue 3, Pages 390-393Publisher
CELL PRESS
DOI: 10.1016/j.cell.2013.01.010
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Telomere shortening impairs proliferation of transformed cells but also leads to cancer initiation by inducing chromosomal instability. Here, we discuss recent developments in our understanding of the role of telomeres in replication stress and how telomerase expression in somatic stem cells may affect genome integrity control and carcinogenesis.
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