Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 60, Issue 11, Pages 2389-2401Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-003-3037-4
Keywords
B-Myb; E2F; p107; cyclin/cdk; phosphorylation; cell cycle; gene repression; transcriptional regulation
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The expression of genes required for progression through the cell cycle is highly modulated through a regulatory axis containing the E2F transcription factor and retinoblastoma tumour suppressor protein families. One of the genes regulated through this mechanism encodes the B-Myb transcription factor, which has been shown to be critically required for early embryonal development in the mouse. Transcriptional activity of B-Myb is substantially enhanced in S phase through modification by cyclin A/cdk2, and the evidence points squarely to the major role being played by B-Myb during this phase of the cell cycle. We discuss in this review recent findings suggesting that B-Myb is a multifunctional protein that has, in addition to its transcriptional properties, the ability to interact directly with other regulators of the cell cycle.
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