Journal
CELL
Volume 155, Issue 2, Pages 308-320Publisher
CELL PRESS
DOI: 10.1016/j.cell.2013.08.058
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Funding
- NIH [T32GM007288, F31HD066967, T32GM007491, F31 NS076243, T32GM07491, 5R01HD055380, R21NS081505, P30HD071593, P30CA013330]
- Fulbright fellowship
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Sensory dendrites depend on cues from their environment to pattern their growth and direct them toward their correct target tissues. Yet, little is known about dendrite-substrate interactions during dendrite morphogenesis. Here, we describe MNR-1/menorin, which is part of the conserved Fam151 family of proteins and is expressed in the skin to control the elaboration of menorah-like dendrites of mechanosensory neurons in Caenorhabditis elegans. We provide biochemical and genetic evidence that MNR-1 acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites. Our data describe an unknown pathway that provides spatial information from the skin substrate to pattern sensory dendrite development nonautonomously.
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