Journal
NATURE REVIEWS CANCER
Volume 3, Issue 11, Pages 807-820Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc1208
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The cytostatic and apoptotic functions of transforming growth factor-beta (TGF-beta) help restrain the growth of mammalian tissues; loss of these effects leads to hyperproliferative disorders and is common in cancer. However, tumour cells that are relieved from TGF-beta growth constraints might then overproduce this cytokine to create a local immunosuppressive environment that fosters tumour growth and exacerbates the invasive and metastatic behaviour of the tumour cells themselves. For these reasons, there is a growing interest in understanding and therapeutically targeting TGF-beta-mediated processes in cancer progression.
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