Journal
CELL
Volume 153, Issue 3, Pages 513-515Publisher
CELL PRESS
DOI: 10.1016/j.cell.2013.04.018
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Funding
- Cancer Research UK [11224] Funding Source: researchfish
- Cancer Research UK [11224] Funding Source: Medline
- Wellcome Trust [092096] Funding Source: Medline
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Trimethylation of histone H3 on Lys36 (H3K36me3) by SETD2 is linked to actively transcribed regions. Li et al. identify a novel role for H3K36me3 that facilitates DNA mismatch repair (MMR) in cells by targeting the MMR machinery to chromatin during the cell cycle, thereby explaining certain cases of MMR-defective cancers.
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