Journal
PHYTOTHERAPY RESEARCH
Volume 17, Issue 9, Pages 1082-1087Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/ptr.1324
Keywords
Prunella vulgaris; organic fraction; phenolic acids; DPPH radical assay; metal-ion complexes; low-density lipoprotein; cytoprotectivity; antiproliferative; antimicrobial activity
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The organic fraction (OF; 25.7% w/w of rosmarinic acid) of Prunella vulgaris (total extract) was found to exhibit the following: scavenging activity on diphenylpicrylhydrazyl radical (DPPH), inhibition of in vitro human LDL Cu(II)-mediated oxidation, protection of rat mitochondria and rat hepatocytes exposed to either tert-butyl hydroperoxide, or to Cu(11) and Fe(111) ions. OF also showed a potential to inhibit rat erythrocyte haemolysis and it reduced the production of LTB4 in bovine PMNL generated by the 5-lipoxygenase pathway. Other observations included antiproliferative effects against HaCaT cells and mouse epidermal fibroblasts and a moderate OF antimicrobial activity on gram-positive bacteria. Rosmarinic, caffeic and 3-(3,4-dihydroxyphenyl)lactic acids exhibited less potent activity than the plant extract in all bioassays. The antioxidative, antimicrobial, together with antiviral effects offer good prospects for the medicinal applications of P. vulgaris. Copyright (C) 2003 John Wiley Sons, Ltd.
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