Journal
NATURE REVIEWS NEUROSCIENCE
Volume 4, Issue 11, Pages 873-884Publisher
NATURE RESEARCH
DOI: 10.1038/nrn1247
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The endocannabinoids are a family of lipid messengers that engage the cell surface receptors that are targeted by Delta(9)-tetrahydrocannabinol, the active principle in marijuana ( Cannabis). They are made on demand through cleavage of membrane precursors and are involved in various short-range signalling processes. In the brain, they combine with CB1 cannabinoid receptors on axon terminals to regulate ion channel activity and neurotransmitter release. Their ability to modulate synaptic efficacy has a wide range of functional consequences and provides unique therapeutic possibilities.
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