Journal
CELL
Volume 152, Issue 6, Pages 1252-1269Publisher
CELL PRESS
DOI: 10.1016/j.cell.2013.02.034
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Funding
- NIH [R01 GM067842, R01 GM095296, U54 HG007005, U54 HG006994]
- Canadian Institutes of Health Research
- Canadian Cancer Society
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Ontario Research Fund
- European Molecular Biology Organization
- Human Frontier Science Program Fellowships
- NSERC Studentship
- NRSA Fellowship
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Precursor mRNA splicing is one of the most highly regulated processes in metazoan species. In addition to generating vast repertoires of RNAs and proteins, splicing has a profound impact on other gene regulatory layers, including mRNA transcription, turnover, transport, and translation. Conversely, factors regulating chromatin and transcription complexes impact the splicing process. This extensive crosstalk between gene regulatory layers takes advantage of dynamic spatial, physical, and temporal organizational properties of the cell nucleus, and further emphasizes the importance of developing a multidimensional understanding of splicing control.
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