Journal
PEPTIDES
Volume 24, Issue 11, Pages 1705-1712Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2003.09.014
Keywords
plant defensin; sphingolipid; glucosylceramide; Neurospora crassa; Saccharomyces cerevisiae; Pichia pastoris; Candida albicans; mode of action
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Plant defensins are small, basic, cysteine-rich peptides that are generally active against a broad spectrum of fungal and yeast species at micromolar concentrations. Some of these defensins interact with fungal-specific lipid components in the plasmamembrane. Structural differences of these membrane components between fungal and plant cells probably account for the selective activity of plant defensins against fungal pathogens and their nonphytotoxic properties. This review will focus on different classes of complex lipids in fungal membranes and on the selective interaction of plant defensins with these complex lipids. (C) 2003 Elsevier Inc. All rights reserved.
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