Journal
CELL
Volume 154, Issue 4, Pages 827-842Publisher
CELL PRESS
DOI: 10.1016/j.cell.2013.07.039
Keywords
-
Categories
Funding
- CARE-MI FP7 [Health-F5-2010-242038]
- Endostem FP7 [Health F5-2010-241440]
- Marie Curie International Reintegration FP7 Grant [PIRG02-GA-2007-224853]
- FIRB-Futuro-in-Ricerca [RBFR081CCS]
- Italian Ministry of Health [GR-2008-1142673]
- Associazione Italiana per la Ricerca sul Cancro (AIRC) MFAG
- Istituto Superiore di Sanita [RF-CAL-2008-1261292]
Ask authors/readers for more resources
The epidemic of heart failure has stimulated interest in understanding cardiac regeneration. Evidence has been reported supporting regeneration via transplantation of multiple cell types, as well as replication of postmitotic cardiomyocytes. In addition, the adult myocardium harbors endogenous c-kit(pos) cardiac stem cells (eCSCs), whose relevance for regeneration is controversial. Here, using different rodent models of diffuse myocardial damage causing acute heart failure, we show that eCSCs restore cardiac function by regenerating lost cardiomyocytes. Ablation of the eCSC abolishes regeneration and functional recovery. The regenerative process is completely restored by replacing the ablated eCSCs with the progeny of one eCSC. eCSCs recovered from the host and recloned retain their regenerative potential in vivo and in vitro. After regeneration, selective suicide of these exogenous CSCs and their progeny abolishes regeneration, severely impairing ventricular performance. These data show that c-kit(pos) eCSCs are necessary and sufficient for the regeneration and repair of myocardial damage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available