Journal
CELL
Volume 148, Issue 1-2, Pages 33-45Publisher
CELL PRESS
DOI: 10.1016/j.cell.2012.01.002
Keywords
-
Categories
Funding
- UK Medical Research Council (MRC)
- MRC
- Wellcome Trust
- Cancer Research UK
- European Union
- Cambridge University
- Hutchison Whampoa
Ask authors/readers for more resources
Lineage tracing is the identification of all progeny of a single cell. Although its origins date back to developmental biology of invertebrates in the 19th century, lineage tracing is now an essential tool for studying stem cell properties in adult mammalian tissues. Lineage tracing provides a powerful means of understanding tissue development, homeostasis, and disease, especially when it is combined with experimental manipulation of signals regulating cell-fate decisions. Recently, the combination of inducible recombinases, multicolor reporter constructs, and live-cell imaging has provided unprecedented insights into stem cell biology. Here we discuss the different experimental strategies currently available for lineage tracing, their associated caveats, and new opportunities to integrate lineage tracing with the monitoring of intracellular signaling pathways.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available