Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 145, Issue 1-2, Pages 135-138Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2003.09.003
Keywords
chemokine; CCR2; multiple sclerosis; polymorphism; susceptibility gene; Japanese
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C-C chemokine receptor 2 (CCR2) is a receptor for chemoattractant protein-1 (MCP-1) and associated with infiltrating lymphocytes in chronic active multiple sclerosis (MS) lesions. To study the role of CCR2 gene in the development of MS, we investigated the CCR2-64I polymorphism in 122 MS patients and 112 healthy controls in a Japanese population. We also analysed the influence of CCR2-64I polymorphism on the clinical course, age at disease onset, and severity. The distribution of the CCR2-64I allele was significantly different between patients and controls (p = 0.0187), and the 64I/64I homozygote was significantly less common in MS than in control. Logistic analysis, adjusted for HLA-DRB1*1501-positivity, revealed negative association between the CCR2-64I and MS (p = 0.0204). There were no significant associations between CCR2 polymorphism and the clinical features of MS. Our results indicate that the presence of CCR2-64I allele seems to provide protection against the development of MS. (C) 2003 Elsevier B.V All rights reserved.
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