Journal
JOURNAL OF SEPARATION SCIENCE
Volume 26, Issue 18, Pages 1698-1700Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200301616
Keywords
HPTLC; levofloxacin; lamotrigine; tablets
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A new simple, precise, rapid, and selective high-performance thin layer chromatography (HPTLC) method has been developed for the analysis of levofloxacin in pharmaceutical formulations. The method uses lamotrigine as an internal standard. The stationary phase was silica gel 60F(254) prewashed with methanol; water-methanol-n-butanol-ammonia solution 5 + 5 + 5 + 0.4 (v/v) was used as mobile phase. Detection and quantification were performed densitometrically at lambda = 298 nm. The linear range of the analysis was 0.8-3.0 mug and the percentage recovery was 99.90%.
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