Journal
DEVELOPMENTAL DYNAMICS
Volume 228, Issue 4, Pages 623-629Publisher
WILEY-LISS
DOI: 10.1002/dvdy.10403
Keywords
Merkel cell; NT-3; TrkC; p75NTR; neural crest; mechanoreceptor
Categories
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS038500] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS38500] Funding Source: Medline
- PHS HHS [1F05-11111-02] Funding Source: Medline
Ask authors/readers for more resources
Merkel cells are sensory cells of neural crest origin. Because little is known about the mechanisms that direct their differentiation, we have investigated the potential role of a candidate regulatory factor, neurotrophin-3 (NT-3). At embryonic day 16.5 (E 16.5), neither INT-3 nor its primary receptors, TrkC and p75NTR are expressed by Merkel cells in the murine whisker. At the time of birth, however, Merkel cells are immunoreactive for NT-3, TrkC and p75NTR. In TrkC null and NT-3 null mice, Merkel cells differentiate initially, but undergo apoptosis perinatally. These results show that NT-3 signaling is not required for the differentiation of Merkel cells, but that it is essential for their postnatal survival. (C) 2003 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available