Journal
CELL
Volume 149, Issue 5, Pages 968-977Publisher
CELL PRESS
DOI: 10.1016/j.cell.2012.05.007
Keywords
-
Categories
Funding
- NIH [R01 NS49173, R01 GM100453, P01 AI077774]
Ask authors/readers for more resources
The once heretical concept that a misfolded protein is the infectious agent responsible for prion diseases is now widely accepted. Recent exciting research has led not only to the end of the skepticism that proteins can transmit disease, but also to expanding the concept that transmissible proteins might be at the root of some of the most prevalent human illnesses. At the same time, the idea that biological information can be transmitted by propagation of protein (mis) folding raises the possibility that heritable protein agents may be operating as epigenetic factors in normal biological functions and participating in evolutionary adaptation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available