Journal
CELL
Volume 150, Issue 5, Pages 1002-1015Publisher
CELL PRESS
DOI: 10.1016/j.cell.2012.07.017
Keywords
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Categories
Funding
- ERC
- ALW-ERAPG [855.50.017]
- EMBO-ALTF [1114-2006]
- CONACYT [000000000092916]
- Ministerio de Educacion y Ciencia, Spain
- Marie Curie IEF [IEF-2008-237643]
- Dorothy Hodgkin Fellowship
- UK Biological and Biotechnology Research Council (BBSRC) [BB/J004553/1]
- NWO VIDI grant
- NIH [R01-GM043778]
- Swedish Research Council
- Carl Tryggers Stiftelse grants
- BBSRC [BB/G00482X]
- ERASysBio+ initiative under the EU FP7 ERA-NET Plus scheme
- BBSRC [BBS/E/J/000C0646, BB/E022383/1, BB/G00482X/1, BB/J009199/1, BB/E022383/2, BBS/E/J/000C0645] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000C0646, BB/J009199/1, BB/E022383/1, BBS/E/J/000C0645, BB/E022383/2, BB/G00482X/1] Funding Source: researchfish
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In plants, where cells cannot migrate, asymmetric cell divisions (ACDs) must be confined to the appropriate spatial context. We investigate tissue-generating asymmetric divisions in a stem cell daughter within the Arabidopsis root. Spatial restriction of these divisions requires physical binding of the stem cell regulator SCARECROW (SCR) by the RETINOBLASTOM-RELATED (RBR) protein. In the stem cell niche, SCR activity is counteracted by phosphorylation of RBR through a cyclinD6;1-CDK complex. This cyclin is itself under transcriptional control of SCR and its partner SHORT ROOT (SHR), creating a robust bistable circuit with either high or low SHR-SCR complex activity. Auxin biases this circuit by promoting CYCD6;1 transcription. Mathematical modeling shows that ACDs are only switched on after integration of radial and longitudinal information, determined by SHR and auxin distribution, respectively. Coupling of cell-cycle progression to protein degradation resets the circuit, resulting in a flip flop that constrains asymmetric cell division to the stem cell region.
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