Journal
CELL
Volume 149, Issue 3, Pages 515-524Publisher
CELL PRESS
DOI: 10.1016/j.cell.2012.04.005
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Funding
- United States Public Health Service from the National Institutes of Health [R01-CA133404]
- Cancer Center from the National Cancer Institute [P30-CA14051]
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Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as post-transcriptional repressors of gene expression, microRNAs (miRNAs) help to confer robustness to biological processes by reinforcing transcriptional programs and attenuating aberrant transcripts, and they may in some network contexts help suppress random fluctuations in transcript copy number. These activities have important consequences for normal development and physiology, disease, and evolution. Here, we will discuss examples and principles of miRNAs that contribute to robustness in animal systems.
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