Journal
CELL
Volume 148, Issue 6, Pages 1172-1187Publisher
CELL PRESS
DOI: 10.1016/j.cell.2012.02.005
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Funding
- Cancer Prevention and Research Institute of Texas (CPRIT)
- National Institutes of Health (NIH) [R01CA120185, P01CA134292, R01HL77439, R01HL093039, U01HL100401]
- Robert A. Welch Foundation
- American Heart Association-Jon Holden DeHaan Foundation
- D.W. Reynolds Center for Clinical Cardiovascular Research
- Leducq Transatlantic Network of Excellence in Cardiovascular Research
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Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics.
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