Journal
CELL
Volume 150, Issue 5, Pages 873-875Publisher
CELL PRESS
DOI: 10.1016/j.cell.2012.08.008
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Funding
- NINDS NIH HHS [P01NS050210, RC1 NS068280] Funding Source: Medline
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Single-stranded RNAs interact with components of the RNA interference pathway to reduce the expression of target mRNAs. Now, Lima et al. and Yu et al. show that, with extensive chemical modifications, small single-stranded RNAs can robustly induce gene silencing with efficacy similar to their double-stranded counterparts.
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