Journal
CELL
Volume 150, Issue 5, Pages 877-879Publisher
CELL PRESS
DOI: 10.1016/j.cell.2012.08.010
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- Cancer Research UK [14256] Funding Source: researchfish
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Cytoplasmic dynein is a motor essential for numerous mechanical processes in eukaryotic cells. How its activity is regulated is largely unknown. By using a combination of approaches including single-molecule biophysics and electron microscopy, Huang et al. in this issue uncover the regulatory mechanism by which LIS1 controls the activity of cytoplasmic dynein.
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