Journal
CELL
Volume 148, Issue 1-2, Pages 46-57Publisher
CELL PRESS
DOI: 10.1016/j.cell.2012.01.003
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Funding
- Glenn Foundation for Medical Research
- NIH [P01 AG036695, R37 AG23806]
- Ellison Medical Foundation
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The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges.
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