Journal
MOLECULAR IMMUNOLOGY
Volume 39, Issue 11, Pages 615-647Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0161-5890(02)00252-3
Keywords
apoptosis; Bcl-2; bax; BH3-only; mitochondria; caspases; caspase-independent; lymphocyte survival
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Members of the Bcl-2 family are crucial integrators of survival and death signals in higher eukaryotes. Although recent studies have provided novel and quite unexpected insights into the mechanisms by which these proteins might issue life permits or death sentences in cells, we are still on the way to fully understand their modes of action. This review provides a snapshot on where we are on this journey and how we may exploit our knowledge on this family of proteins to unveil the mysteries of immune regulation. (C) 2003 Elsevier Science Ltd. All rights reserved.
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